Microneedling is a safe, minimally invasive and effective esthetic treatment for several different dermatologic conditions including fine lines, wrinkles, acne scars, enlarged pores, pigmentation disorders and stretch marks. Additionally it leads to tightening of loose skin. Skin micro-acupuncture is a treatment that naturally increases the production of skin collagen. It is a device with multiple micro or nano-needles resulting in creation of microchannels. A controlled skin injury with minimal epidermal damage is induced and the dermal wound healing cascade is stimulated. This leads to the release of various growth factors. Fibroblast proliferation is achieved and neovascularization and neocollagenesis follows, process that occurs over weeks. This way the body reacts and produces new collagen and elastin in the dermis. Usually 4-6 sessions are required depending on the skin’s condition and age. After each session an erythema will be present for a few hours while in the next 3-4 days the skin will have a rougher sensation as the dead cells are removed. In addition, this treatment allows for the simultaneous administration of valuable substances to the skin when combined with heterologous mesotherapy, PRP (Plasma Rich of platelet), or Vitamin C maximizing the outcome of the treatment.